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Fouke and his fellow researchers examined more than 50 kidney stone fragments from six Mayo Clinic patients using various light and electron microscopes. They identified organic matter and calcium crystals with ultraviolet light, which uses different wavelengths to make distinct minerals glow. The researchers examined more than 50 kidney stone fragments from six Mayo Clinic patients.CreditMayandi Sivaguru, Jessica Saw from Bruce Fouke Lab, Carl R. Woese Institute for Genomic Biology, U. of I. A high-resolution method, called Airyscan super-resolution microscopy, captured colorful snapshots of organic matter and crystal layers in the kidney stones, “crosscut and truncated” by newer crevices, triangles and other geometrics, Dr. Fouke said. The disruptive patterns in the stones showed that the vast majority of the material had dissolved and reformed over time. Doctors often base patient care plans upon the chemistry and molecular components of a patient’s urine.

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